Ribosomal mechanics, antibiotics, and GTP hydrolysis

Previous studies on bacterial ribosomes have established that L11-ribosomal RNA (rRNA) plays a key role in regulating ribosomal factor-dependent processes, including G proteins and GTPases activities. It was also found that GTPase-associated ribosomal site controls ribosomal factor binding and GTP hydrolysis by undergoing some conformational changes. The site has ben observed to be composed of two primary ribosomal components that include the protein-rRNA cluster and a pentameric L10(L12)4 complex.