The gene for cherubism maps to chromosome 4p16

The gene for cherubism, an autosomal dominant disorder perhaps related to tooth development and eruption and resulting in altered facial appearance and large amounts of fibrous tissue in the jaws, has been mapped to chromosome 4p16. A genomewide search has been carried out in a 3-generation family. Three other affected families were genotyped and mapped to the locus, which is across an interval of about 22 cM.