Differential regulation of functional responses by beta-adrenergic receptor subtypes in brown adipocytes

Primary brown adipocyte cultures were employed to determine the role of beta-adrenergic receptor (beta-AR) subtypes in mediating lipolysis and uncoupling protein-1 gene expression, elicited by the physiological neurohormone norepinephrine (NE). Findings indicated that beta-AR subtypes regulate various physiological responses stimulated by NE in brown adipocyte cultures in part by differentially transducing signals to subcellular compartments.