Prox1 (ital) function is required for the development of the murine lymphatic system

Function of Prox1 (ital), a homeobox gene which is necessary for development of the murine lymphatic system, is discussed. The gene is expressed in a subpopulation of endothelial cells that give rise through budding and sprouting to the lymphatic system. The budding and sprouting is arrested in Prox1 (ital) null mice, but angiogenesis and vasculogenesis of the vascular system are not affected.