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Substance P and capsaicin release prostaglandin E2 from rat intrapulmonary bronchi
- Source :
- The American Journal of Physiology. Nov, 1998, Vol. 275 Issue 5, pL1006, 7 p.
- Publication Year :
- 1998
-
Abstract
- Research was conducted to examine the hypothesis that substance P and capsaicin would cause the release of prostaglandin E2 (PGE2) from isolated airway segments. The effects of C-fiber desensitization, neurokinin (NK1)-receptor antagonism, cyclooxygenase inhibition and epithelium removal on release of the PG by substance P and by activation of the sensory nerve inhibitory system were investigated. Results indicate that activation of NK1 receptors on epithelium causes release of PGE2.
Details
- ISSN :
- 00029513
- Volume :
- 275
- Issue :
- 5
- Database :
- Gale General OneFile
- Journal :
- The American Journal of Physiology
- Publication Type :
- Academic Journal
- Accession number :
- edsgcl.56337115