Selective recognition of mannose by the human eosinophil Charcot-Leyden crystal protein (Galectin-10): a crystallographic study at 1.8 A resolution

The Charcot-Leyden crystal (CLC) protein has been one of the most interesting subjects of biochemistry research due to its undetermined link with eosinophil functions. Diffraction data derived from a sample of CLC cyrstals, however, suggest that these proteins do not actually have affinity for beta-galactosides. Results further indicate that CLC proteins bind with mannose in a manner distinct with other galectin compounds.