Chronic phospholamban-sarcoplasmic reticulum calcium ATPase interaction is the critical calcium cycling defect in dilated cardiomyopathy

Chronic phospholamban (PLB)-sarcoplasmic reticulum calcium ATPase interaction is discussed as the critical calcium cycling defect in dilated cardiomyopathy. A study has used a genetic complementation strategy in a well-known mouse model of dilated cardiomyopathy. It is deficient in the cytoskeletal LIM protein, which is muscle-specific. Progressive defects in excitation-contraction coupling are related to enhancement of inhibition of SER-CA2a by PLB. Inhibition of PLB expression or PLB-SERCA2a interaction can prevent heat failure.