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Syntheses of alternating oligo-2'-O-methylribonucleotide methylphosphonates and their interactions with HIV TAR RNA
- Source :
- Biochemistry. Nov 16, 1999, Vol. 38 Issue 46, p15333, 10 p.
- Publication Year :
- 1999
-
Abstract
- Oligonucleotides have been synthesized that can bind to TAR RNA and are resistant to nuclease degradation. TAR RNA regulates HIV replication and these oligonucleotides could be used as antisense drugs to block viral replication.
- Subjects :
- Antisense nucleic acids -- Research
HIV (Viruses)
Biological sciences
Chemistry
Subjects
Details
- ISSN :
- 00062960
- Volume :
- 38
- Issue :
- 46
- Database :
- Gale General OneFile
- Journal :
- Biochemistry
- Publication Type :
- Academic Journal
- Accession number :
- edsgcl.58663018