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Synthetic somatostatin analog (Octreotide) suppresses daytime growth hormone secretion equivalently in young and older men: preserved pituitary responsiveness to somatostatin's inhibition in aging
Synthetic somatostatin analog (Octreotide) suppresses daytime growth hormone secretion equivalently in young and older men: preserved pituitary responsiveness to somatostatin's inhibition in aging
- Source :
- Journal of the American Geriatrics Society. Dec, 1999, Vol. 47 Issue 12, p1422, 3 p.
- Publication Year :
- 1999
-
Abstract
- A randomized controlled study of growth hormone (GH) secretion when synthetic somatostatin analog (Octreotide) is being used. It was found that it suppresses daytime growth hormone secretion similarly in older men and young men. Pituitary responsiveness to somatostatin's inhibition is preserved in aging. Nine younger men, aged 35-44 and ten older men, aged 62-79, were studied. Likely daytime relative GH deficiency seen in older men is not from excessive pituitary susceptiility to somatostatin. More likely it is from impoverished endogenous GH releasing hormone (RH) drive or higher release of brain somatostatin. susceptiility
Details
- ISSN :
- 00028614
- Volume :
- 47
- Issue :
- 12
- Database :
- Gale General OneFile
- Journal :
- Journal of the American Geriatrics Society
- Publication Type :
- Periodical
- Accession number :
- edsgcl.59358352