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Synthetic somatostatin analog (Octreotide) suppresses daytime growth hormone secretion equivalently in young and older men: preserved pituitary responsiveness to somatostatin's inhibition in aging

Synthetic somatostatin analog (Octreotide) suppresses daytime growth hormone secretion equivalently in young and older men: preserved pituitary responsiveness to somatostatin's inhibition in aging

Authors :
Mulligan, Thomas
Jaen-Vinuales, Alejandro
Veldhuis, Johannes D.
Godschalk, Michael
Iranmanesh, Ali
Source :
Journal of the American Geriatrics Society. Dec, 1999, Vol. 47 Issue 12, p1422, 3 p.
Publication Year :
1999

Abstract

A randomized controlled study of growth hormone (GH) secretion when synthetic somatostatin analog (Octreotide) is being used. It was found that it suppresses daytime growth hormone secretion similarly in older men and young men. Pituitary responsiveness to somatostatin's inhibition is preserved in aging. Nine younger men, aged 35-44 and ten older men, aged 62-79, were studied. Likely daytime relative GH deficiency seen in older men is not from excessive pituitary susceptiility to somatostatin. More likely it is from impoverished endogenous GH releasing hormone (RH) drive or higher release of brain somatostatin. susceptiility

Details

ISSN :
00028614
Volume :
47
Issue :
12
Database :
Gale General OneFile
Journal :
Journal of the American Geriatrics Society
Publication Type :
Periodical
Accession number :
edsgcl.59358352