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8-oxodGTP incorporation by DNA polymerase beta is modified by active-site residue Asn279

Authors :
Miller Holly
Prasad Rajendra
Wilson, Samuel H.
Johnson, Francis
Grollman, Arthur
Source :
Biochemistry. Feb 8, 2000, Vol. 39 Issue 5, p1029, 5 p.
Publication Year :
2000

Abstract

Results show that interaction between 8-oxodGTP and aspergine 279 at the DNA polymerase site probably alters conformation of the 8-oxodGTP resulting in its misincorporation by the polymerase.

Details

ISSN :
00062960
Volume :
39
Issue :
5
Database :
Gale General OneFile
Journal :
Biochemistry
Publication Type :
Academic Journal
Accession number :
edsgcl.59623837