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Mutation of the iron ligand His 249 to Glu in the N-lobe of human transferrin abolishes the dilysine 'trigger' but does not significantly affect iron release

Authors :
MacGillivray, Ross T.A.
Bewley, Maria C.
Smith, Clyde A.
He, Qing-Yu
Mason, Anne B.
Woodworth, Robert C.
Baker, Edward N.
Source :
Biochemistry. Feb 15, 2000, Vol. 39 Issue 6, p1211, 6 p.
Publication Year :
2000

Abstract

Research has been conducted on the effect of histidine ligand of human transferin on iron binding. Site-directed mutagenesis, spectroscopy and structural analysis are examined.

Details

ISSN :
00062960
Volume :
39
Issue :
6
Database :
Gale General OneFile
Journal :
Biochemistry
Publication Type :
Academic Journal
Accession number :
edsgcl.59697650