Role of Close Endocervical Margin in Treatment Failure After Cervical Excision for Cervical Intraepithelial Neoplasia: A Retrospective Study

* Context.--A significant negative trend in length of cone excision has been observed in recent years, leading to a higher percentage of positive endocervical excision margin and close ( Objective.--To evaluate the rate of disease persistence and recurrence after cervical excision for cervical intraepithelial neoplasia in relation to a close ( Design.--We retrospectively analyzed a cohort of patients with cervical intraepithelial neoplasia having a carbon dioxide laser cervical excision performed by the same operator. We evaluated the rate of positive follow-up in relation to the status of endocervical margin. Results.--We found a higher percentage of positivity at follow-up and recurrence rate between 13 and 24 months in patients with positive margin than for patients with negative or close endocervical margin (P =.005 and P = .006, respectively), with no difference between negative and close margin (7.0% versus 8.3%, P =.89, and 1.2% versus 0%, P =.83, respectively). Conclusions.--Women with close and negative endocervical margin presented similar risk of positivity at longterm follow-up, disease persistence, and recurrence between 13 and 24 months, so the histopathologic report of a free endocervical margin less than 1 mm should not categorize the patient as being at increased risk of treatment failure. Therefore, the only information that the pathologist should report is the state of the margin (positive or negative), regardless of the negative endocervical margin length. (Arch Pathol Lab Med. 2019;143:1006-1011; doi:10.5858/arpa.2018-0363-OA)
Cervical intraepithelial neoplasia (CIN) is a potentially premalignant lesion of the uterine cervix, with a risk of progression to invasive cervical cancer related to the severity and size of the [...]