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Increasing Numbers and Reported Adverse Events in Patients with Lung Cancer Undergoing Inpatient Lung Biopsies: A Population-Based Analysis

Authors :
von Itzstein, Mitchell S.
Gupta, Arjun
Mara, Kristin C.
Khanna, Sahil
Gerber, David E.
Source :
Lung. October, 2019, Vol. 197 Issue 5, p593, 7 p.
Publication Year :
2019

Abstract

Introduction The use of molecular biomarkers to guide lung cancer management has led to increasing frequency and amounts of tissue required for repeat lung biopsies. While patient safety and reporting of adverse events has been increasingly emphasized in recent decades, the safety of lung biopsies in patients with lung cancer has only been studied in small cohorts. We therefore analyzed adverse events in patients with lung cancer undergoing lung biopsies in the National Hospital Discharge Survey (NHDS) database. Methods Data were abstracted using ICD-9 lung cancer diagnosis (162.X) and lung biopsy procedure codes (33.20, 33.24, 33.25, 33.26, 33.27, 33.28) from 2001 to 2010. Agency for Healthcare Research and Quality (AHRQ) Patient-Safety Indicators (PSI) were used to identify hospital-acquired adverse events. Weighted analyses were performed using SAS version 9.4. Results A total of 540,747 patients were included for analysis. The number of biopsies increased over time, from 51,221 in 2001, to 63,239 in 2010 (P < 0.001). Overall, 159,683 (30%) patients suffered [greater than or equal to] 1-PSI event during their hospitalization. Incidence of PSI varied by biopsy type: bronchoscopic (26%), percutaneous (34%), surgical (39%). The proportion of patients with [greater than or equal to] 1 PSI event increased from 24% in 2001 to 38% in 2010 (P < 0.001). Patients with [greater than or equal to] 1 PSI had longer length of stay (mean, 11.6 vs 8.1 days; P < 0.001) and higher in-hospital mortality (adjusted odds ratio, 5.9, 95% CI 3.9-8.9; P < 0.001). Conclusions The frequency of lung biopsies performed and rate of documented adverse events in hospitalized lung cancer patients have increased. These findings have policy, funding, research, and practice implications.<br />Author(s): Mitchell S. von Itzstein [sup.1] , Arjun Gupta [sup.1] [sup.6] , Kristin C. Mara [sup.2] , Sahil Khanna [sup.3] , David E. Gerber [sup.1] [sup.4] [sup.5] [sup.7] Author Affiliations: [...]

Details

Language :
English
ISSN :
03412040
Volume :
197
Issue :
5
Database :
Gale General OneFile
Journal :
Lung
Publication Type :
Academic Journal
Accession number :
edsgcl.601867203
Full Text :
https://doi.org/10.1007/s00408-019-00255-y