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Activation of antitumor cytotoxic T lymphocytes by fusions of human dendritic cells and breast carcinoma cells
- Source :
- Proceedings of the National Academy of Sciences of the United States. March 14, 2000, Vol. 97 Issue 6, 2715
- Publication Year :
- 2000
-
Abstract
- We have reported that fusions of murine dendritic cells (DCs) and murine carcinoma cells reverse unresponsiveness to tumor-associated antigens and induce the rejection of established metastases. In the present study, fusions were generated with primary human breast carcinoma cells and autologous DCs. Fusion cells coexpressed tumor-associated antigens and DC-derived costimulatory molecules. The fusion cells also retained the functional potency of DCs and stimulated autologous T cell proliferation. Significantly, the results show that autologous T cells are primed by the fusion cells to induce MHC class I-dependent lysis of autologous breast tumor cells. These findings demonstrate that fusions of human breast cancer cells and DCs activate T cell responses against autologous tumors. breast cancer | fusion cells | heterokaryons | DF3A/MUC1 antigen
Details
- ISSN :
- 00278424
- Volume :
- 97
- Issue :
- 6
- Database :
- Gale General OneFile
- Journal :
- Proceedings of the National Academy of Sciences of the United States
- Publication Type :
- Academic Journal
- Accession number :
- edsgcl.61487545