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Histiocytic Sarcoma
- Source :
- Archives of Pathology & Laboratory Medicine. May, 2020, Vol. 144 Issue 5, p650, 5 p.
- Publication Year :
- 2020
-
Abstract
- * Histiocytic sarcoma, a rare malignant neoplasm showing morphologic and immunophenotypic features of histiocytes, is characterized typically by extranodal presentation and a dismal clinical course, particularly in patients with disseminated disease. A history of hematolymphoid disorder can be identified in a subset of patients, suggesting transdifferentiation of a preexisting hematolymphoid neoplasm in its pathogenesis. The differential diagnosis of histiocytic sarcoma includes various lymphomas, other histiocytic and dendritic cell neoplasms, carcinomas, melanomas, and pleomorphic sarcomas. Given its rarity and histologic overlap with diverse mimics, the diagnosis of histiocytic sarcoma can be extremely challenging. Recognition of morphologic clues, as well as judicious application of immunohistochemical markers to confirm its histiocytic lineage and to exclude mimics, is crucial for the diagnosis. Recent molecular studies by targeted next-generation sequencing identified recurrent alterations in the mitogen-activated protein (MAP) kinase pathway and chromatin regulators in the pathogenesis of histiocytic sarcoma and may suggest possible therapeutic targets. (Arch Pathol Lab Med. 2020;144:650-654; doi: 10.5858/arpa.2018-0349-RS)<br />Histiocytic sarcoma is an extremely rare malignancy showing morphologic and immunophenotypic features of histiocytes. While the terms histiocytic sarcoma and histiocytic lymphoma had been used since the 1970s, (1) many [...]
- Subjects :
- Sarcoma
Mitogens
Non-Hodgkin's lymphomas
Dendritic cells
Melanoma
Health
Subjects
Details
- Language :
- English
- ISSN :
- 15432165
- Volume :
- 144
- Issue :
- 5
- Database :
- Gale General OneFile
- Journal :
- Archives of Pathology & Laboratory Medicine
- Publication Type :
- Academic Journal
- Accession number :
- edsgcl.624693848
- Full Text :
- https://doi.org/10.5858/arpa.2018-0349-RS