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Metformin Exerts a Direct Effect on Β Cells and Reverts Alterations Induced by Gluco- or Lipo-Toxicitiy

Authors :
PATANE, GIOVANNI
PIRO, SALVATORE
ANELLO, MARCELLO
RABUAZZO, AGATA M.
VIGNERI, RICCARDO
PURRELLO, FRANCESCO
Source :
Diabetes. May 2000, Vol. 49 Issue 5, A264
Publication Year :
2000

Abstract

We cultured rat pancreatic islets with either high glucose (16.7 mmol/l, 24 h) or FFA (2 mM oleate/palmitate2:1, 48 h) concentrations, and then for additional 24 h in the presence [...]

Details

Language :
English
ISSN :
00121797
Volume :
49
Issue :
5
Database :
Gale General OneFile
Journal :
Diabetes
Publication Type :
Periodical
Accession number :
edsgcl.62892326