General solid-phase method for the preparation of mechanism-based cysteine protease inhibitors

Authors :: Lee, Alice
Huang, Lily
Ellman, Jonathan A.
Source :: Journal of the American Chemical Society. Nov 3, 1999, Vol. 121 Issue 43, p9907, 8 p.
Publication Year :: 1999
Abstract: Research is presented describing the solid-phase synthesis of cysteine protease inhibitors which are ketone-based. The fully substituted ketone products occur in 40-100% overall yields after they are released from the support by transformations and cleavage.

Subjects :: Amides -- Research
Chemical bonds -- Research
Cysteine -- Research
Ketones -- Research
Proteases -- Research
Thin layer chromatography -- Usage
Chemistry

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