3-hydroxykynurenine and 3-hydroxyanthranilic acid generate hydrogen peroxide and promote alpha-crystallin cross-linking by metal ion reduction

Authors :: Goldstein, Lee E.
Leopold, Michael C.
Huang, Xudong
Atwood, Craig S.
Saunders, Aleister J.
Hartshorn, Mariana
Lim, James T.
Faget, Kyle Y.
Muffat, Julien A.
Scarpa, Richard C.
Chylack, Leo T., Jr.
Bowden, Edmond F.
Tanzi, Rudolph E.
Bush, Ashley I.
Source :: Biochemistry. June 20, 2000, Vol. 39 Issue 24, p7266, 10 p.
Publication Year :: 2000
Abstract: Research has been conducted on the kynurenine pathway catabolites. The reaction of these catabolites with iron and copper and interactions with alpha-crystallins have been investigated.

Subjects :: Biochemistry -- Research
Acids -- Research
Hydrogen peroxide -- Research
Metal ions -- Research
Metabolism -- Analysis
Iron -- Analysis
Copper -- Analysis
Biological sciences
Chemistry

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