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Hypoxia-inducible factor signaling in pulmonary hypertension
- Source :
- Journal of Clinical Investigation. November, 2020, Vol. 130 Issue 11, p5638, 14 p.
- Publication Year :
- 2020
-
Abstract
- Pulmonary hypertension (PH) is characterized by pulmonary artery remodeling that can subsequently culminate in right heart failure and premature death. Emerging evidence suggests that hypoxia-inducible factor (HIF) signaling plays a fundamental and pivotal role in the pathogenesis of PH. This Review summarizes the regulation of HIF isoforms and their impact in various PH subtypes, as well as the elaborate conditional and cell-specific knockout mouse studies that brought the role of this pathway to light. We also discuss the current preclinical status of pan- and isoform-selective HIF inhibitors, and propose new research areas that may facilitate HIF isoform-specific inhibition as a novel therapeutic strategy for PH and right heart failure.<br />HIF signaling and biology The transcription factor hypoxia-inducible factor (HIF) is a master regulator of oxygen homeostasis that acts as a heterodimeric complex composed of the oxygen-sensitive [alpha] subunit (HIF-[alpha]; [...]
Details
- Language :
- English
- ISSN :
- 00219738
- Volume :
- 130
- Issue :
- 11
- Database :
- Gale General OneFile
- Journal :
- Journal of Clinical Investigation
- Publication Type :
- Academic Journal
- Accession number :
- edsgcl.641057609
- Full Text :
- https://doi.org/10.1172/JCI137558