Mitf from neural crest to melanoma: signal transduction and transcription in the melanocyte lineage

Signal transduction and transcription in the melanocyte lineage are discussed in this review article. Gene expression and how it is controlled in neural crest-derived melanocytes by interaction of specific transcription factors and signal transduction pathways are emphasized along with regulation of the expression and function of the microphthalmia-associated transcription factor, Mitf. Mouse studies and zerbrafish studies will be valuable in the study of melanocyte development. It will give novel insights into the integration of gene expression and signal transduction pathways and how they control development of a specific cell lineage.