Cell cycle-regulated phosphorylation of p220(super.NPAT) by cyclin E/Cdk2 in Cajal bodies promotes histone gene transcription

Cell cycle-regulated phosphorylation of p220(super.NPAT) by cyclin E/Cdk2 in Cajal bodies has been shown to promote histone gene transcription. In investigation of how cyclin E/Cdk2 controls S-phase events, the subcellular localization of the cyclin E/Cdk2 interacting protein p220(super.NPAT) and its regulation by phosphorylation was studied, and it was found that p220 is localized to discrete nuclear foci. Five cyclin E/Cdk2 phosphorylation sites in p220 were found.