Optimizing Compression Coating for Pulsatile Release Tablets: Research examined the effects of varying excipient and polymer weight in coatings designed to optimize release of diclofenac sodium, with the goal of releasing it at night to improve the treatment of rheumatoid arthritis

As the fields of chronopharmaceutics and chronophar-macology (1) reveal more about the importance of circadian rhythms with respect to human physiology, disease state, and drug action, time-controlled pulsatile-release tablets are [...]