Fludarabine compared with chlorambucil as primary therapy for chronic lymphocytic leukemia

Authors :: Rai, Kanti R.
Peterson, Bercedis L.
Applebaum, Frederick R.
Kolitz, Jonathan
Elias, Laurence
Shepherd, Lois
Hines, John
Threatte, Gregory A.
Larson, Richard A.
Cheson, Bruce D.
Schiffer, Charles A.
Source :: The New England Journal of Medicine. Dec 14, 2000, Vol. 343 Issue 24, p1750, 8 p.
Publication Year :: 2000
Abstract: Fludarabine may be effective in treating chronic lymphocytic leukemia that does not respond to chlorambucil. In a study of 509 patients, fludarabine resulted in higher response rates and longer remissions but did not improve overall survival rates.

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