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High-resolution structure of hte HNF-1alpha dimerization domain
- Source :
- Biochemistry. Dec 12, 2000, Vol. 39 Issue 49, p15062, 9 p.
- Publication Year :
- 2000
-
Abstract
- The dimerization of hepatocyte nuclear factor (HNF) 1alpha occurs through a hydrophobic surface that also binds the transcriptional coactivator DCoH. A mutation in HNF 1alpha has been linked to maturity-onset diabetes of the young type 3.
Details
- ISSN :
- 00062960
- Volume :
- 39
- Issue :
- 49
- Database :
- Gale General OneFile
- Journal :
- Biochemistry
- Publication Type :
- Academic Journal
- Accession number :
- edsgcl.70357990