Hormone Replacement Therapy, Prothrombotic Mutations, and the Risk of Incident Nonfatal Myocardial Infarction in Postmenopausal Women

Postmenopausal women who have hypertension, use hormone replacement therapy, and have a gene mutation that predisposes them to produce blood clots have over 10 times the risk of having a heart attack compared to women with none of those risk factors. This was the conclusion of a study of 955 postmenopausal women, 232 of whom had a heart attack.