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Geometric, Scaling Effects in Electrical Field Flow Fractionation. 1. Theoretical Analysis

Authors :
Gale, Bruce K.
Caldwell, Karin D.
Frazier, A. Bruno
Source :
Analytical Chemistry. May 15, 2001, Vol. 73 Issue 10, 2345
Publication Year :
2001

Abstract

This work outlines the fundamental scaling laws associated with electrical field flow fractionation channels. Although general FFF theory indicates few advantages from miniaturization, EFFF theory indicates clear advantages to miniaturization of the EFFF channel. Retention, plate heights, resolution, equilibration times, and time constants are examined. The outlined theory predicts scaling advantages in each of these areas after miniaturization. Potential applications, such as the use of these systems for sample preparation in microscale total analysis systems, and improvements associated with these theoretical predictions are also discussed.

Details

ISSN :
00032700
Volume :
73
Issue :
10
Database :
Gale General OneFile
Journal :
Analytical Chemistry
Publication Type :
Academic Journal
Accession number :
edsgcl.75374909