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Chalcone derivatives antagonize interactions between the human oncoprotein MDM2 and p53
- Source :
- Biochemistry. Jan 16, 2001, Vol. 40 Issue 2, p336, 9 p.
- Publication Year :
- 2001
-
Abstract
- Research has been conducted on the oncoprotein MDM2 inhibiting the tumor suppressor protein p53. Results of the multidimensional NMR spectroscopy indicate that chalcones are MDM2's inhibitors binding to the p53 binding cleft substrate of human MDM2.
Details
- ISSN :
- 00062960
- Volume :
- 40
- Issue :
- 2
- Database :
- Gale General OneFile
- Journal :
- Biochemistry
- Publication Type :
- Academic Journal
- Accession number :
- edsgcl.77076859