Synergistic interactions of multiple mutations on catalysis during the hydroxylation reaction of p-hydroxybenzoate hydroxylase: studies of the Lys297Met, Asn300Asp, and Tyr385Phe mutants reconstituted with 8-C1-flavin

Authors :: Ortiz-Maldonado, Mariliz
Aeschliman, Sara M.
Ballou, David P.
Massey, Vincent
Source :: Biochemistry. July 31, 2001, Vol. 40 Issue 30, p8705, 12 p.
Publication Year :: 2001
Abstract: Research has been conducted on the catalysis of the p-hydroxybenzoate by p-hydroxybenzoate hydroxylase. The results of the oxygen transfer to p-hydroxybenzoate via C4a-hydroperoxide of the flavin are described.

Subjects :: Biochemistry -- Research
Gene mutations -- Physiological aspects
Catalysis -- Physiological aspects
Hydroxylation -- Physiological aspects
Oxygen -- Physiological aspects
Biological sciences
Chemistry

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