Enhancer-promoter specificity mediated by DPE or TATA core promoter motifs

Recent study has shown the existence of transcriptional enhancers that are specific for promoters that contain either TATA box or downstream promoter element (DPE) elements. The core promoter is seen to mediate initiation of transcription and also to act as a regulatory element. The ability of enhancers to activate transcription in vivo from core promoters having either DPE or TATA box motifs was studied to look into the basis for enhancer-promoter specificity.