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Genetic insights into the mechanisms of proliferative glomerulonephritis
- Source :
- Journal of Clinical Investigation. August 1, 2024, Vol. 134 Issue 15
- Publication Year :
- 2024
-
Abstract
- Glomerular visceral epithelial cells (i.e., podocytes) are an essential component of the tripartite glomerular filtration barrier. Healthy podocytes are terminally differentiated cells with limited replicative capacity; however, inappropriate cell cycle reentry can be induced in podocytes by various injurious stimuli. In this issue of the JCI, Yamaguchi et al. report on a somatic mosaic gain-of-function mutation in the phosphatidylinositol4,5- bisphosphate 3-kinase catalytic a subunit (p110[alpha], encoded by PIK3CA). The study reveals that activating mutations of p110[alpha] can drive podocyte proliferation in PIK3CA-related overgrowth syndrome (PROS). They also showed that selective, small-molecule inhibitors of p110 may be useful for the treatment of proliferative glomerulonephritis.<br />The podocyte Podocytes are specialized, postmitotic cells with essential functions in the maintenance of glomerular tuft architecture and ultrafiltration (Figure 1A) (1). As terminally differentiated cells, podocytes express high levels [...]
- Subjects :
- Health care industry
Subjects
Details
- Language :
- English
- ISSN :
- 00219738
- Volume :
- 134
- Issue :
- 15
- Database :
- Gale General OneFile
- Journal :
- Journal of Clinical Investigation
- Publication Type :
- Academic Journal
- Accession number :
- edsgcl.807442603
- Full Text :
- https://doi.org/10.1172/JCI183090