Diastereoselective kinetic protonation of exocyclic enolates derived from bicyclic ketones: control of stereochemistry mediated by bridging heteroatoms

Authors :: Davies, Huw M. L.
Hodges, L. Mark
Gregg, Timothy M.
Source :: Journal of Organic Chemistry. Nov 16, 2001, Vol. 66 Issue 23, p7898, 5 p.
Publication Year :: 2001
Abstract: Research has been conducted on the bridging heteroatom beta. The hypothesis that the heteroatom attached beta to the carbonyl mediates the steric or electronic barrier to the transition state in protonating the enolate from the top or exo face has been investigated and is reported.

Subjects :: Chemistry, Organic -- Research
Ketones -- Physiological aspects
Stereochemistry -- Research
Atoms -- Models
Carbonyl compounds -- Physiological aspects
Biological sciences
Chemistry

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