PIASy, a nuclear matrix-associated SUMO E3 ligase, represses LEF1 activity by sequestration into nuclear bodies

Research has been conducted on the Wnt-responsive transcription factor lymphoid enhancer factor 1 (LEF1) which activates transcription in association with beta-catenin and represses transcription in association with Groucho. The additional regulatory mechanisms of the LEF1 function have been investigated via the identified as an interaction partner of LEF1 protein which inhibits the activated signal transducers and activators of transcription and protein inhibitor of activated STAT, and the details are reported.