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N(sup)4C--ethyl--N(sup)4C cross-linked DNA: synthesis and characterization of duplexes with interstrand cross-links of different orientations
- Source :
- Biochemistry. Jan 22, 2002, Vol. 41 Issue 3, p760, 12 p.
- Publication Year :
- 2002
-
Abstract
- This articles describes the synthesis of N(sup)4C--ethyl--N(sup)4C interstrand cross-linked DNA duplexes employing N(sup)4C--ethyl--N(sup)4C phosphoramidite reagent. The ligated oligomers containing staggered cross-links exhibit differences in structure and stability with -GC- staggered cross-links disrupt hydrogen bonding and affecting helix stability by perturbing adjacent base pairs.
Details
- ISSN :
- 00062960
- Volume :
- 41
- Issue :
- 3
- Database :
- Gale General OneFile
- Journal :
- Biochemistry
- Publication Type :
- Academic Journal
- Accession number :
- edsgcl.83535973