Function of extracellular loop 2 in Rhodopsin: glutamic acid 181 modulates stability and absorption wavelength of metarhodopsin II

Authors :: Yan, Elsa C.Y.
Kazmi, Manija A.
De, Soma
Chang, Belinda S.W.
Seibert, Christoph
Marin, Ethan P.
Mathies, Richard A.
Sakmar, Thomas P.
Source :: Biochemistry. March 19, 2002, Vol. 41 Issue 11, p3620, 8 p.
Publication Year :: 2002
Abstract: Results demonstrate that the second extracellular loop 2 of rhodopsin renders the chromophore-binding domain inaccessible to solvent. The glutamine 181 makedly affects the retinylidene Schiff base of the active metarhodopsin II.

Subjects :: Rhodopsin -- Analysis
Proteins -- Structure
Structure-activity relationships (Biochemistry) -- Analysis
G proteins -- Research
Biological sciences
Chemistry

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