Back to Search Start Over

Efficacy of the ketogenic diet for infantile spasms

Authors :
Kossoff, Eric H.
Pyzik, Paula L.
McGrogan, Jane R.
Vining, Eileen P.G.
Freeman, John M.
Source :
Pediatrics. May, 2002, Vol. 109 Issue 5, p780, 4 p.
Publication Year :
2002

Abstract

Objective. The objective of this study was to determine whether the ketogenic diet is safe, well-tolerated, and efficacious in the treatment of infantile spasms. Methods. During a 4-year period, 23 children with infantile spasms, aged 5 months to 2 years, were started on the ketogenic diet; 9 (39%) had symptomatic infantile spasms, and 16 (70%) had hypsarrhythmia. Children had an average prediet exposure to 3.3 anticonvulsants. Two children were enrolled before any medication had been tried. Seizure reduction was analyzed retrospectively, using parent reports and electroencephalograms (EEGs) when available. Results. At 3, 6, 9, and 12 months, 38%, 39%, 53%, and 46%, respectively, of all patients currently on the diet were >90% improved (3 were seizure-free at 12 months); 67%, 72%, 93%, and 100% were >50% improved. Fifty-six percent remained on the diet at 12 months, 46% of whom were >90% improved and 100% were >50%. Fifty percent of those with hypsarrhythmia and follow-up EEGs had EEG improvement. Fifty-seven percent had their medications reduced or discontinued by 12 months. Fifty-seven percent had improvement in development, which was correlated with seizure control. Independent factors that predicted improvement included age younger than 1 year and previous exposure to 3 or fewer anticonvulsants. No child has died, and 7 children had diet-related adverse reactions (nephrolithiasis, gastroesophageal reflux). Discussion. The ketogenic diet is a safe, well-tolerated, and possibly effective potential alternative to other therapies for infantile spasms. Pediatrics 2002;109:780-783; infantile spasms, ketogenic diet, seizures.<br />Infantile spasms are a generalized seizure disorder characterized by clusters of sudden flexor or extensor jerks in infants who are younger than 1 year. (1,2) It is associated with both [...]

Details

ISSN :
00314005
Volume :
109
Issue :
5
Database :
Gale General OneFile
Journal :
Pediatrics
Publication Type :
Academic Journal
Accession number :
edsgcl.86168740