Total synthesis of (S)-(+)-imperanene. Effective use of regio- and enantioselective intramolecular carbon-hydrogen insertion reactions catalyzed by chiral dirhodium(II) carboxamidates

Research has been conducted on the Chinese medicine natural product, (S)-(+)-imperanene. The synthesis of this compound has been carried out from the cinnamic acid by the enantioselective carbon-hydrogen insertion from the diazoacetate via the use of the chiral dirhodium(II) carboxamidate catalyst and the details are described.