Simple entry to 3'-substituted analogues to anti-HIV agent stavudine based on an anionic O (approaches) C stannyl migration

Research has been conducted on the anti-HIV agent stavudine. The reaction of the 5'-O-protected derivative of this agent with LTMP has been investigated in the presence of HMPA in an attempt to lithiate vinylic hydrogens and the results indicate that the reaction has triggered anionic silyl migration to produce 3'-C-silylated product.