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Rotational-echo double resonance characterization of vancomycin binding sites in Staphylococcus aureus

Authors :
Kim, Sung Joon
Cegelski Lynette
Studelska, Daniel R.
O'Connor, Robert D.
Mehta, Anil K.
Schaefer, Jacob
Source :
Biochemistry. June 4, 2002, Vol. 41 Issue 22, p6967, 11 p.
Publication Year :
2002

Abstract

Results demonstrate that the vancomycin analogue LY329332 binds to peptidoglycan of Staphylococcus aureus in a monomeric form as determined by the rotational-echo double resonance magic angle spinning nuclear magnetic resonance spectoscopy. Characterization of the in situ structure of the antibiotic binding site in the cell wall peptidoglycan is presented.

Subjects

Subjects :
Antibiotics -- Structure-activity relationships
Vancomycin -- Analysis
Nuclear magnetic resonance -- Analysis
Binding sites (Biochemistry) -- Analysis
Biological sciences
Chemistry

Details

ISSN :
00062960
Volume :
41
Issue :
22
Database :
Gale General OneFile
Journal :
Biochemistry
Publication Type :
Academic Journal
Accession number :
edsgcl.87706249

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