Regio- and stereoselective ring openings of 3-aza-2-oxabicyclo[2.2.1]hept-5-ene systems with copper catalyst-modified Grignard reagents: application to the synthesis of an inhibitor of 5-lipoxygenase

Research has been conducted on the acylnitroso hetero Diels-Alder cycloadducts. Results indicate that the treatment of these cycloadducts with the organomagnesium reagents carried out in the presence of copper induces ring opening and produces monocyclic anti-1,2-hydroxamic acids.