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A novel mechanism for Clostridium botulinum neurotoxin inhibition

Authors :
Eswaramoorthy, Subramaniam
Kumaran, Desigan
Swaminathan, Subramanyam
Source :
Biochemistry. August 6, 2002, Vol. 41 Issue 31, p9795, 8 p.
Publication Year :
2002

Abstract

Crystal structure of Clostridium botulinum neurotoxin type B in complex with the inhibitor reveals that during the course of enzyme inhibition, the active site rearranges and zinc ion is gradually removed from the active site causing loss of catalytic activity.

Subjects

Subjects :
Proteins -- Structure
Crystals -- Structure
Enzyme kinetics -- Analysis
Botulinum toxin -- Analysis
Binding sites (Biochemistry) -- Analysis
Biological sciences
Chemistry

Details

ISSN :
00062960
Volume :
41
Issue :
31
Database :
Gale General OneFile
Journal :
Biochemistry
Publication Type :
Academic Journal
Accession number :
edsgcl.90689839

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