The MexR repressor of the mexAB-oprM multidrug efflux operon in Pseudomonas aeruginosa: characterization of mutations compromising activity

Authors :: Adewoye, Lateef
Sutherland, Ainsley
Srikumar, Ramakrishnan
Poole, Keith
Source :: Journal of Bacteriology. August, 2002, Vol. 184 Issue 15-16, p4308, 5 p.
Publication Year :: 2002
Abstract: The mexR gene encoded product MexR in nalB mutants of Pseudomonas aeruginosa is modified by a single amino acid that compromizes the stability of the protein or its ability to dimerize. However, modification of L95 and R21 amino acid residues confer stability and dimerization capability but compromises DNA binding.

Subjects :: Drug resistance in microorganisms -- Genetic aspects
Gene mutations -- Analysis
Proteins -- Structure
Structure-activity relationships (Biochemistry) -- Analysis
Biological sciences

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