Solution and biologically relevant conformations of enantiomeric 11-cis-locked cyclopropyl retinals

Authors :: Fujimoto, Yukari
Fishkin, Nathan
Pescitelli, Gennaro
Decatur, John
Berova, Nina
Nakanishi, Koji
Source :: Journal of the American Chemical Society. June 26, 2002, Vol. 124 Issue 25, p7294, 9 p.
Publication Year :: 2002
Abstract: Nuclear magnetic resonance analysis reveal that 11-cis-locked cyclopropyl retinal adopts a twist chair conformation, involving the seven-membered ring, in solution. Data indicate that the compound exists as two diastereomeric populations. The native retinal does not exhibit twist preference around C6/C7 bond.

Subjects :: Visual pigments -- Analysis
Retina -- Composition
Rhodopsin -- Analysis
Structure-activity relationships (Biochemistry) -- Analysis
Chemistry

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