New oxidative transformations of phenolic and indolic oxazolines: an avenue to useful azaspirocyclic building blocks

Research points out that the oxidative cyclization of phenolic omega-arylalkanoic carboxamides to spirolactams can be accomplished using iodobenzene diacetate via oxazoline intermediates. Results suggest that these transformations of the organic hypervalent iodine chemistry are useful in the syntheses of azaspirocyclic products.