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Synthesis of chiral pilocarpine analogues via a C-8 ketone intermediate

Authors :
Holden, Kenneth G.
Mattson, Matthew N.
Cha, Kyung Hoi
Rapoport, Henry
Source :
Journal of Organic Chemistry. August 23, 2002, Vol. 67 Issue 17, p5913, 6 p.
Publication Year :
2002

Abstract

Research has been conducted on the chiral pilocarpine analogue. The synthesis of this analogue where the lactone ring is replaced by oxazolidinone and the bridging methylene group is in the ketone oxidation state has been carried out and the results are reported.

Subjects

Subjects :
Chemistry, Organic -- Research
Ketones -- Physiological aspects
Chirality -- Physiological aspects
Pilocarpine -- Physiological aspects
Lactones -- Physiological aspects
Oxidation-reduction reaction -- Physiological aspects
Biological sciences
Chemistry

Details

ISSN :
00223263
Volume :
67
Issue :
17
Database :
Gale General OneFile
Journal :
Journal of Organic Chemistry
Publication Type :
Academic Journal
Accession number :
edsgcl.92203434

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