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IL-2 negatively regulates IL-7 receptor [alpha] chain expression in activated T lymphocytes
- Source :
- Proceedings of the National Academy of Sciences of the United States. Oct 15, 2002, Vol. 99 Issue 21, p13759, 6 p.
- Publication Year :
- 2002
-
Abstract
- Interleukin (IL)-2 is a type I four-[alpha]-helical bundle cytokine that plays vital roles in antigen-mediated proliferation of peripheral blood T cells and also is critical for activation-induced cell death. We now demonstrate that IL-2 potently decreases expression of IL-7 receptor [alpha] chain (IL-7R[alpha]) mRNA and protein. The fact that IL-7R[alpha] is a component of the receptors for both IL-7 and thymic stromal lymphopoietin (TSLP) suggests that IL-2 can negatively regulate signals by each of these cytokines. Previously it was known that the IL-2 and IL-7 receptors shared the common cytokine receptor [gamma] chain, [[gamma].sub.c] which suggested a possible competition between these cytokines for a receptor component. Our findings now suggest a previously unknown type of cross-talk between IL-2 and IL-7 signaling by showing that IL-2 signaling can diminish IL-7R[alpha] expression via a phosphatidylinositol 3-kinase/Akt-dependent mechanism.
Details
- ISSN :
- 00278424
- Volume :
- 99
- Issue :
- 21
- Database :
- Gale General OneFile
- Journal :
- Proceedings of the National Academy of Sciences of the United States
- Publication Type :
- Academic Journal
- Accession number :
- edsgcl.94131487