Characterization of a Mycobacterium tuberculosis H37Rv transposon library reveals insertions in 351 ORFs and mutants with altered virulence

Authors :: McAdam, Ruth A.
Quan, Selwyn
Smith, Debbie A.
Bardarov, Stoyan
Betts, Joanna C.
Cook, Fiona C.
Hooker, Elizabeth U.
Lewis, Alan P.
Woollard, Peter
Everett, Martin J.
Lukey, Pauline T.
Bancroft, Gregory J.
Jacobs, William R., Jr.
Duncan, Ken
Source :: Microbiology. Oct, 2002, Vol. 148 Issue 10, p2975, 12 p.
Publication Year :: 2002
Abstract: Research has been conducted on Mycobacterium tuberculosis virulence. The identification of the genes important for this virulence has been carried out via the use of transposon mutagenesis and the results indicate that this approach allowes to recognize each mutant and provides the candidates to screen in vivo.

Subjects :: Microbiological research -- Analysis
Mycobacterium tuberculosis -- Physiological aspects
Virulence (Microbiology) -- Genetic aspects
Virulence (Microbiology) -- Research
Gene mutations -- Physiological aspects
Transposons -- Genetic aspects
Mutagenesis -- Physiological aspects
Biological sciences

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