Mutagenesis by acrolein-derived propanodeoxyguanosine adducts in human cells

Research has been conducted on acrolien, a member of the alpha, beta-unsaturated aldehyde family. The role of alpha-OH-1,N (super)2 ?propanodeoxyguanosine adduct in the genotoxicity of this acrolein has been investigated via comparison of alpha-OH-1,N (super)2 ?propanodeoxyguanosine, gamma-OH-1,N (super)2 ?propanodeoxyguanosine and propanodeoxyguanosine by in vitro primer extension studies and in human cells and the details are reported.