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Solution structure of a DnA duplex containing mispair-aligned N(sup)4C-Ethyl-N(sup)4C interstrand cross-linked cytosines

Authors :
da Silva, Mateus Webba
Noronha, Anne M.
Noll, David M.
Miller, Paul S.
Colvin, O. Michael
Gamcsik, Michael P.
Source :
Biochemistry. Dec 24, 2002, Vol. 41 Issue 51, p15181, 8 p.
Publication Year :
2002

Abstract

Results show that the cross-link N(sup)4C-Ethyl-N(sup)4C interstrand in the undecamer deoxyoligonucleotide imitates the BCNU-induced G-C cross-link and the C-C cross-link, rendering this DNA duplex recognizable by different DNA repair mechanisms.

Details

ISSN :
00062960
Volume :
41
Issue :
51
Database :
Gale General OneFile
Journal :
Biochemistry
Publication Type :
Academic Journal
Accession number :
edsgcl.96394559