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Regulatory gene networks and the properties of the developmental process

Authors :
Davidson, Eric H.
McClay, David R.
Hood, Leroy
Source :
Proceedings of the National Academy of Sciences of the United States. Feb 18, 2003, Vol. 100 Issue 4, p1475, 6 p.
Publication Year :
2003

Abstract

Genomic instructions for development are encoded in arrays of regulatory DNA. These specify large networks of interactions among genes producing transcription factors and signaling components. The architecture of such networks both explains and predicts developmental phenomenology. Although network analysis is yet in its early stages, some fundamental commonalities are already emerging. Two such are the use of multigenic feedback loops to ensure the progressivity of developmental regulatory states and the prevalence of repressive regulatory interactions in spatial control processes. Gene regulatory networks make it possible to explain the process of development in causal terms and eventually will enable the redesign of developmental regulatory circuitry to achieve different outcomes.

Details

ISSN :
00278424
Volume :
100
Issue :
4
Database :
Gale General OneFile
Journal :
Proceedings of the National Academy of Sciences of the United States
Publication Type :
Academic Journal
Accession number :
edsgcl.98371187