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Zika Virus: Medical Countermeasure Development Challenges
- Source :
- Malone, R. W., J. Homan, M. V. Callahan, J. Glasspool-Malone, L. Damodaran, A. D. B. Schneider, R. Zimler, et al. 2016. “Zika Virus: Medical Countermeasure Development Challenges.” PLoS Neglected Tropical Diseases 10 (3): e0004530. doi:10.1371/journal.pntd.0004530. http://dx.doi.org/10.1371/journal.pntd.0004530.
- Publication Year :
- 2016
- Publisher :
- Public Library of Science, 2016.
-
Abstract
- Introduction: Reports of high rates of primary microcephaly and Guillain–Barré syndrome associated with Zika virus infection in French Polynesia and Brazil have raised concerns that the virus circulating in these regions is a rapidly developing neuropathic, teratogenic, emerging infectious public health threat. There are no licensed medical countermeasures (vaccines, therapies or preventive drugs) available for Zika virus infection and disease. The Pan American Health Organization (PAHO) predicts that Zika virus will continue to spread and eventually reach all countries and territories in the Americas with endemic Aedes mosquitoes. This paper reviews the status of the Zika virus outbreak, including medical countermeasure options, with a focus on how the epidemiology, insect vectors, neuropathology, virology and immunology inform options and strategies available for medical countermeasure development and deployment. Methods: Multiple information sources were employed to support the review. These included publically available literature, patents, official communications, English and Lusophone lay press. Online surveys were distributed to physicians in the US, Mexico and Argentina and responses analyzed. Computational epitope analysis as well as infectious disease outbreak modeling and forecasting were implemented. Field observations in Brazil were compiled and interviews conducted with public health officials.
- Subjects :
- People and places
Geographical locations
South America
Brazil
Medicine and Health Sciences
Public and Occupational Health
Biology and Life Sciences
Physiology
Immune Physiology
Antibodies
Immunology
Immune System Proteins
Biochemistry
Proteins
Infectious Diseases
Viral Diseases
Chikungunya Infection
Pulmonology
Respiratory Infections
Epidemiology
Infectious Disease Epidemiology
Disease Vectors
Insect Vectors
Mosquitoes
Organisms
Animals
Invertebrates
Arthropoda
Insects
Arboviral Infections
Subjects
Details
- Language :
- English
- ISSN :
- 19352727
- Database :
- Digital Access to Scholarship at Harvard (DASH)
- Journal :
- Malone, R. W., J. Homan, M. V. Callahan, J. Glasspool-Malone, L. Damodaran, A. D. B. Schneider, R. Zimler, et al. 2016. “Zika Virus: Medical Countermeasure Development Challenges.” PLoS Neglected Tropical Diseases 10 (3): e0004530. doi:10.1371/journal.pntd.0004530. http://dx.doi.org/10.1371/journal.pntd.0004530.
- Publication Type :
- Academic Journal
- Accession number :
- edshld.1.26318641
- Document Type :
- Journal Article
- Full Text :
- https://doi.org/10.1371/journal.pntd.0004530